If you encounter below error message while uploading iOS App version to itunesconnect using Application Loader
ERROR ITMS-90168: "The binary you uploaded was invalid. "The resulting API analysis file is too large. We were unable to validate your API prior to delivery
Then This is the most common reason that it is related to outdated application loader version. Make sure your Mac OS X version is up to date and the application loader tool & X code versions are up to date.